Zellbiologie neurologischer Erkrankungen

Vollständige Publikationsliste

Vollständige Publikationsliste der Abteilung Zellbiologie neurologischer Erkrankungen

Ausgewählte Publikationen 2024

Jucker M, Walker LC (2024) Evidence for the iatrogenic transmission of Alzheimer's disease. Nature Medicine 30(2):344-345 (Abstract)

Ausgewählte Publikationen 2023

Jucker M, Walker LC (2023) Alzheimer's disease: From immunotherapy to immunoprevention. Cell 186(20):4260-4270 (Abstract)

Ausgewählte Publikationen 2022

Rother C, Uhlmann RE, Müller SA, Schelle J, Skodras A, Obermüller U, Häsler LM, Lambert M, Baumann F, Xu Y, Bergmann C, Salvadori G, Loos M, Brzak I, Shimshek D, Neumann U, Dominantly Inherited Alzheimer Network, Walker LC, Schulz SA, Chhatwal JP, Kaeser SA, Lichtenthaler SF, Staufenbiel M, Jucker M (2022) Experimental evidence for temporal uncoupling of brain Aβ deposition and neurodegenerative sequelae. Nat Commun 13:7333 (Abstract)

Eninger T, Müller SA, Becioglu M, Schweighauser M, Lambert M, Maia LF, Neher JJ, Hornfeck SM, Obermüller U, Kleinberger G, Haass C, Kahle PJ, Staufenbiel M, Ping L, Duong DM, Levey AI, Seyfried NT, Lichtenthaler SF, Jucker M, Kaeser SA (2022) Signatures of glial activity can be detected in the CSF proteome. Proc Natl Acad Sci USA 119(24):e2119804119 (Abstract)

Kaeser SA, Häsler LM, Lambert M, Bergmann C, Bottelbergs A, Theunis C, Mercken M, Jucker M (2022) CSF p-tau increase in response to Aβ-type and Danish-type cerebral amyloidosis and in the absence of neurofibrillary tangles. Acta Neuropathol. 143(2):287-290(Abstract)

Wagner J, Degenhardt K, Veit M, Louros N, Konstantoulea K, Skodras A, Wild K, Liu P, Obermüller U, Bansal V, Dalmia A, Häsler LM, Lambert M, De Vleeschouwer M, Davies HA, Madine J, Kronenberg-Versteeg D, Feederle R, Del Turco D, Nilsson KPR, Lashley T, Deller T, Gearing M, Walker LC, Heutink P, Rousseau F, Schymkowitz J, Jucker M, Neher JJ (2022) Medin co-aggregates with vascular amyloid-β in Alzheimer's disease. Nature 612:7938 (Abstract)

Ausgewählte Publikationen 2021

Kaeser SA, Lehallier B, Thinggaard M, Häsler LM, Apel A, Bergmann C, Berdnik D, Jeune B, Christensen K, Grönke S, Partridge L, Wyss-Coray T, Mengel-From J, Jucker M (2021) A neuronal blood marker is associated with mortality in old age. Nature Aging 1:218-225 (Abstract)

Wagner J, Neher JJ (2021) Killing ageing neurons, one cell at a time. Nature Neuroscience 24:759-760 (Abstract)

Barth M, Bacioglu M, Schwarz N, Novotny R, Brandes J, Welzer M, Mazzitelli S, Häsler LM, Schweighauser M, Wuttke TV, Kronenberg-Versteeg D, Fog K, Ambjørn M,Alik A, Melki R, Kahle PJ, Shimshek DR, Koch H, Jucker M, Tanriöver G (2021) Microglial inclusions and neurofilament light chain release follow neuronal α-synuclein lesions in long-term brain slice cultures. Mol Neurodegener 16(1):54 (Abstract)

Neher JJ (2021) Reversal of immune-cell shutdown protects the ageing brain. Nature 590(7844):44-45

Ausgewählte Publikationen 2020

Uhlmann RE, Rother C, Rasmussen J, Schelle J, Bergmann C, Ullrich Gavilanes EM, Fritschi SK, Buehler A, Baumann F, Skodras A, Al-Shaana R, Beschorner N, Ye L, Kaeser SA, Obermüller U, Christensen S, Kartberg F, Stavenhagen JB, Rahfeld JU, Cynis H, Qian F, Weinreb PH, Bussiere T, Walker LC, Staufenbiel M, Jucker M (2020) Acute targeting of preamyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life. Nature Neuroscience 23: 12. 1580-1588 (Abstract)

Degenhardt K, Wagner J, Skodras A, Candlish M, Koppelmann AJ, Wild K, Maxwell R, Rotermund C, von Zweydorf F, Gloeckner CJ, Davies HA, Madine J, Del Turco D, Feederle R, Lashley T, Deller T, Kahle P, Hefendehl JK, Jucker M, Neher JJ (2020) Medin aggregation causes cerebrovascular dysfunction in aging wild-type mice. Proc Natl Acad Sci USA 117: 38. 23925-23931 (Abstract)

Tanriöver G, Bacioglu M, Schweighauser M, Mahler J, Wegenast-Braun BM, Skodras A, Obermüller U, Barth M, Kronenberg-Versteeg D, Nilsson KPR, Shimshek DR, Kahle PJ, Eisele YS, Jucker M (2020) Prominent microglial inclusions in transgenic mouse models of α-synucleinopathy that are distinct from neuronal lesions. Acta Neuropathol Commun 8: 1. (Abstract)

Ausgewählte Publikationen 2019

Schelle J, Wegenast-Braun BM, Fritschi SK, Kaeser SA, Jährling N, Eicke D, Skodras A, Beschorner N, Obermueller U, Häsler LM, Wolfer DP, Mueggler T, Shimshek DR, Neumann U, Dodt HU, Staufenbiel M, Jucker M (2019) Early Aβ reduction prevents progression of cerebral amyloid angiopathy. Annals of Neurology 86:561-571 (Abstract)

Neher JJ, Cunningham C (2019) Priming Microglia for Innate Immune Memory in the Brain. Trends in immunology 40:358-374 (Abstract)

Preische O, Schultz SA, Apel A, Kuhle J, Kaeser SA, Barro C, Gräber S, Kuder-Buletta E, LaFougere C, Laske C, Vöglein J, Levin J, Masters CL, Martins R, Schofield PR, Rossor MN, Graff-Radford NR, Salloway S, Ghetti B, Ringman JM, Noble JM, Chhatwal J, Goate AM, Benzinger TLC, Morris JC, Bateman RJ, Wang G, Fagan AM, McDade EM, Gordon BA, Jucker M (2019) Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer's disease. Nature medicine 25: 2. 277-283 (Abstract)

Ausgewählte Publikationen 2018

Jucker M, Walker LC (2018) Propagation and spread of pathogenic protein assemblies in neurodegenerative diseases. Nature neuroscience 21:1341-1349 (Abstract)

Rasmussen J, Krasemann S, Altmeppen H, Schwarz P, Schelle J, Aguzzi A, Glatzel M, Jucker M (2018) Infectious prions do not induce Aβ deposition in an in vivo seeding model. Acta neuropathologica 135:965-967 (Abstract)

Wendeln AC, Degenhardt K, Kaurani L, Gertig M, Ulas T, Jain G, Wagner J, Häsler LM, Wild K, Skodras A, Blank T, Staszewski O, Datta M, Centeno TP, Capece V, Islam MR, Kerimoglu C, Staufenbiel M, Schultze JL, Beyer M, Prinz M, Jucker M, Fischer A, Neher JJ (2018) Innate immune memory in the brain shapes neurological disease hallmarks. Nature 556:332-338 (Abstract)

Ausgewählte Publikationen 2017

Rasmussen J, Jucker M, Walker LC (2017) A beta seeds and prions: How close the fit?Prion 11: 215-25 (Abstract)

Rasmussen J, Mahler J, Beschorner N, Kaeser SA, Hasler LM, Baumann F, Nystrom S, Portelius E, Blennow K, Lashley T, Fox NC, Sepulveda-Falla D, Glatzel M, Oblak AL, Ghetti B, Nilsson KPR, Hammarstrom P, Staufenbiel M, Walker LC, Jucker M (2017) Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer's disease. Proc Natl Acad Sci USA 114: 13018-23 (Abstract)

Ye L, Rasmussen J, Kaeser SA, Marzesco AM, Obermuller U, Mahler J, Schelle J, Odenthal J, Kruger C, Fritschi SK, Walker LC, Staufenbiel M, Baumann F, Jucker M (2017) A beta seeding potency peaks in the early stages of cerebral beta-amyloidosis. Embo Reports 18: 1536-44 (Abstract)

Füger P, Hefendehl JK, Veeraraghavalu K, Wendeln AC, Schlosser C, Obermuller U, Wegenast-Braun BM, Neher JJ, Martus P, Kohsaka S, Thunemann M, Feil R, Sisodia SS, Skodras A, Jucker M (2017) Microglia turnover with aging and in an Alzheimer's model via long-term in vivo single-cell imaging. Nat Neurosci 20: 1371-6 (Abstract)

Walker LC, Jucker (2017) The Exceptional Vulnerability of Humans to Alzheimer's Disease. Trends Mol Med 23:534-45 (Abstract)

Schelle J, Häsler L, Göpfert JC, Joos TO, Vanderstichele H, Stoops E, Mandelkow EM, Neumann U, Shimshek DR, Staufenbiel M, Jucker M, Kaeser SA (2017) Prevention of tau increase in cerebrospinal fluid of APP transgenic mice suggests downstream effect of BACE1 inhibition. Alzheimers Dement 13:701-9 (Abstract)

Ausgewählte Publikationen 2016

Walker LC, Jucker M (2016) The Malignant Protein Puzzle. Cerebrum cer-04-16 (Abstract) 

Bacioglu M, Maia LF, Preische O, Schelle J, Apel A, Kaeser SA, Schweighauser M, Eninger T, Lambert M, Pilotto A, Shimshek DR, Neumann U, Kahle PJ, Staufenbiel M, Neumann M, Maetzler W, Kuhle J, Jucker M (2016) Neurofilament Light Chain in Blood and CSF as Marker of Disease Progression in Mouse Models and in Neurodegenerative Diseases. Neuron 91:56-66 (Abstract)

Jucker M, Heikenwalder M (2016) Immune receptor for pathogenic alpha-synuclein. Science, 353:1498-9 (Abstract) 

Marzesco AM, Flötenmeyer M, Bühler A, Obermüller U, Staufenbiel M, Jucker M, Baumann F (2016) Highly potent intracellular membrane-associated Aβ seeds. Scientific reports 6:28125 (Abstract)

Walker LC, Schelle J, Jucker M (2016)  The Prion-Like Properties of Amyloid-β Assemblies: Implications for Alzheimer's Disease. Cold Spring Harb Perspect Med 6:7 (Abstract)

Novotny R, Langer F, Mahler J, Skodras A, Vlachos A, Wegenast-Braun BM, Kaeser SA, Neher JJ, Eisele YS, Pietrowski MJ, Nilsson KP, Deller T, Staufenbiel M, Heimrich B, Jucker M (2016) Conversion of Synthetic Aβ to In Vivo Active Seeds and Amyloid Plaque Formation in a Hippocampal Slice Culture Model. J Neurosci 36:5084-93 (Abstract)

Ausgewählte Publikationen 2015

Ye L, Fritschi SK, Schelle J, Obermüller U, Degenhardt K, Kaeser SA, Eisele YS, Walker LC, Baumann F, Staufenbiel M, Jucker M (2015) Persistence of Aβ seeds in APP null mouse brain. Nat Neurosci 18:1559-61 (Abstract)

Ye L, Hamaguchi T, Fritschi SK, Eisele YS, Obermüller U, Jucker M, Walker LC (2015) Progression of Seed-Induced Aβ Deposition within the Limbic Connectome. Brain Pathol 25:743-52 (Abstract)

Varvel NH, Grathwohl SA, Degenhardt K, Resch C, Bosch A, Jucker M, Neher JJ (2015) Replacement of brain-resident myeloid cells does not alter cerebral amyloid-β deposition in mouse models of Alzheimer's disease. J Exp Med 212:1803-9 (Abstract)

Jucker M, Walker LC (2015) Neurodegeneration: Amyloid-β pathology induced in humans. Nature 525:193-4 (Abstract)

Laske C, Sohrabi HR, Jasielec MS, Müller S, Koehler NK, Gräber S, Förster S, Drzezga A, Mueller-Sarnowski F, Danek A, Jucker M, Bateman RJ, Buckles V, Saykin AJ, Martins RN, Morris JC, Dominantly Inherited Alzheimer Network Dian (2015) Diagnostic Value of Subjective Memory Complaints Assessed with a Single Item in Dominantly Inherited Alzheimer's Disease: Results of the DIAN Study. Biomed Res Int 2015:828120 (Abstract)

Laske C, Sohrabi HR, Frost SM, López-de-Ipiña K, Garrard P, Buscema M, Dauwels J, Soekadar SR, Mueller S, Linnemann C, Bridenbaugh SA, Kanagasingam Y, Martins RN, O'Bryant SE (2015) Innovative diagnostic tools for early detection of Alzheimer's disease. Alzheimers Dement 11:561-78 (Abstract)

Laske C, Stellos K, Kempter I, Stransky E, Maetzler W, Fleming I, Randriamboavonjy V (2015) Increased cerebrospinal fluid calpain activity and microparticle levels in Alzheimer's disease. Alzheimers Dement 11:465-74 (Abstract)

Walker LC, Jucker M (2015) Neurodegenerative diseases: Expanding the prion concept. Annu Rev Neurosci 38:87-103 (Abstract)

Maia LF, Kaeser SA, Reichwald J, Lambert M, Obermüller U, Odenthal J, Martus P, Staufenbiel M, Schelle J, Jucker M (2015) Increase of CSF Aß during the very early phase of cerebral Aß deposition in mouse models. EMBO Mol Med 7:895-903 (Abstract)

Mahler J, Morales-Corraliza J, Stolz J, Skodras A, Radde R, Duma CC, Eisele YS, Mazzella MJ, Wong H, Klunk WE, Nilsson KP, Staufenbiel M, Mathews PM, Jucker M, Wegenast-Braun BM (2015) Endogenous murine Aβ increases amyloid deposition in APP23 but not in APPPS1 transgenic mice. Neurobiology of aging 36:2241-7 (Abstract) 

Schweighauser M, Bacioglu M, Fritschi SK, Shimshek DR, Kahle PJ, Eisele YS, Jucker M (2015) Formaldehyde-fixed brain tissue from spontaneously ill alpha-synuclein transgenic mice induces fatal alpha-synucleinopathy in transgenic hosts. Acta Neuropathol 129:157-9 (Abstract)

Ausgewählte Publikationen 2014

Fritschi SK, Langer F, Kaeser S, Maia LF, Portelius E, Pinotsi D, Kaminski CF, Winkler DT, Maetzler W, Keyvani K, Spitzer P, Wiltfang J, Kaminski Schierle GS, Zetterberg H, Staufenbiel M, Jucker M (2014) Highly potent soluble amyloid-β seeds in human Alzheimer brain but not cerebrospinal fluid. Brain 137:2909-15 (Abstract)

Fritschi SK, Cintron A, Ye L, Mahler J, Bühler A, Baumann F, Neumann M, Nilsson KP, Hammarström P, Walker LC, Jucker M (2014) Aβ seeds resist inactivation by formaldehyde. Acta Neuropathol 128:477-84 (Abstract)

Brown GC, Neher JJ (2014) Microglial phagocytosis of live neurons. Nat Rev Neuroscience 15:209-16 (Abstract)

Hefendehl JK, Neher JJ, Sühs RB, Kohsaka S, Skodras A, Jucker M (2014) Homeostatic and injury-induced microglia behavior in the aging brain. Aging Cell 13:60-9 (Abstract) 

Eisele YS, Fritschi SK, Hamaguchi T, Obermüller U, Füger P, Skodras A, Schäfer C, Odenthal J, Heikenwalder M, Staufenbiel M, Jucker M (2014)  Multiple Factors Contribute to the Peripheral Induction of Cerebral β-Amyloidosis. J Neurosci 34:10264-73 (Abstract)

Ausgewählte Publikationen 2013 

Walker LC, Jucker M (2013) Seeds of dementia. Sci Am 308:52-7 (Abstract)

Eisele YS (2013)  From soluble Aβ to progressive Aβ aggregation: could prion-like templated misfolding play a role? Brain Pathol 23: 3. 333-341 (Abstract)

Veeraraghavalu K*, Zhang C*, Miller S*, Hefendehl JK*, Rahapaksha TW*, Ulrich J*, Jucker M#, Holtzman DM#, Tanzi RE#, Vassar R#, Sisodia SS# (2013) Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models". Science 24;340:924-f (*authors contributed equally, #corresponding authors) (Abstract) 

Neher JJ, Emmrich JV, Fricker M, Mander PK, Théry C, Brown GC (2013) Phagocytosis executes delayed neuronal death after focal brain ischemia. Proc Natl Acad Sci USA 110:E4098-107 (Abstract)

Maia LF, Kaeser SA, Reichwald J, Hruscha M, Martus P, Staufenbiel M, Jucker M (2013) Changes in Amyloid-β and Tau in the Cerebrospinal Fluid of Transgenic Mice Overexpressing Amyloid Precursor Protein. Sci Transl Med 5:194re2. (Abstract)

Grathwohl SA, Jucker M (2013) Replacement of osmotic minipumps to extend the intracerebral infusion time of compounds into the mouse brain. Biotechniques 55:75-8 (Abstract)

Jucker M, Walker LC (2013) Self-propagation of pathogenic protein aggregates in neurodegenerative diseases. Nature 501:45-51 (Abstract)

Heilbronner G, Eisele YS, Langer F, Kaeser SA, Novotny R, Nagarathinam A, Aslund A, Hammarström P, Nilsson KP, Jucker M (2013) Seeded strain-like transmission of β-amyloid morphotypes in APP transgenic mice. EMBO Rep 14:1017-22 (Abstract)

Nagarathinam A, Höflinger P, Bühler A, Schäfer C, McGovern G, Jeffrey M, Staufenbiel M, Jucker M, Baumann F (2013) Membrane-anchored aβ accelerates amyloid formation and exacerbates amyloid-associated toxicity in mice. J Neurosci 33:19284-94 (Abstract) 

Ausgewählte Publikationen 2012

Hamaguchi T, Eisele YS, Varvel NH, Lamb BT, Walker LC, Jucker M (2012) The presence of Aβ seeds, and not age per se, is critical to the initiation of Aβ deposition in the brain. Acta Neuropathol 123:31-7 (Abstract)

Rosen RF, Fritz JJ, Dooyema J, Cintron AF, Hamaguchi T, Lah JJ, Levine H 3rd, Jucker M, Walker LC (2012) Exogenous seeding of cerebral β-amyloid deposition in βAPP-transgenic rats. J Neurochem 120:660-6 (Abstract)

Hefendehl JK, Milford D, Eicke D, Wegenast-Braun BM, Calhoun ME, Grathwohl SA, Jucker M, Liebig C (2012)  Repeatable target localization for long-term in vivo imaging of mice with 2-photon microscopy. J Neurosci Meth 205:357-63 (Abstract)

Eisenberg D, Jucker M (2012) The amyloid state of proteins in human diseases. Cell 148:1188-203 (Abstract)

Varvel NH, Grathwohl SA, Baumann F, Liebig C , Bosch A, Brawek B, Thal DR, Charo IF, Heppner FL, Aguzzi A, Garaschuk O, Ransohoff RM, Jucker M (2012) Microglial repopulation model reveals a robust homeostatic process for replacing CNS myeloid cells. PNAS 109:18150-5 (Abstract)

Wegenast-Braun BM, Skodras A, Bayraktar G, Mahler J, Fritschi SK, Klingstedt T, Mason JJ, Hammarstrom P, Nilsson KP, Liebig C, Jucker M (2012) Spectral discrimination of cerebral amyloid lesions after peripheral application of luminescent conjugated oligothiophenes. Am J Pathol 181:1953-60 (Abstract)

Ausgewählte Publikationen 2011 

Hefendehl JK*, Wegenast-Braun BM*, Liebig C, Eicke D, Milford D, Calhoun ME, Kohsaka S, Eichner M, Jucker M (2011) Long-term in vivo imaging of β-amyloid plaque appearance and growth in a mouse model of cerebral β-amyloidosis. J Neuroscience 31:624-9 (Abstract)

Langer F, Eisele YS, Fritschi SK, Staufenbiel M, Walker LC, Jucker M (2011) Soluble Aβ seeds are potent inducers of cerebral β-amyloid deposition, J Neuroscience 31:14488-95 (Abstract)

Roesli C, Fugmann T, Borgia B, Schliemann C, Neri D, Jucker M (2011) The accessible cerebral vascular proteome in a mouse model of cerebral β-amyloidosis. J Proteomics 7:539-46 (Abstract) 

Rupp NJ, Wegenast-Braun BM, Radde R, Calhoun ME, Jucker M (2011) Early onset amyloid lesions lead to severe neuritic abnormalities and local, but not global neuron loss in APPPS1 transgenic mice. Neurobiol Aging 32:2324.e1-6 (Abstract)

Walker LC, Jucker M (2011) Amyloid by default. Nat Neurosci 14:669-70 (Abstract)

Jucker M, Walker LC (2011) Pathogenic protein seeding in Alzheimer disease and other neurodegenerative disorders. Ann Neurol 70:532-40 (Abstract)

Kilger E, Buehler A, Woelfing H, Kumar S, Kaeser SA, Nagarathinam A, Walter J, Jucker M, Coomaraswamy J (2011) BRI2 protein regulates β-Amyloid degradation by increasing levels of secreted Insulin-degrading enzyme (IDE). J Biol Chem 286:37446-57 (Abstract)

Ausgewählte Publikationen 2010 

Coomaraswamy J, Kilger E, Wölfing H, Schäfer S, Kaeser SA, Wegenast-Braun BM, Hefendehl JK, Wolburg H, Mazzella M, Ghiso J, Goedert M, Akiyama H, Garcia-Sierra F, Wolfer DP, Mathews PM, Jucker M (2010) Modeling Familial Danish Dementia in mice supports the concept of the amyloid hypothesis of Alzheimer´s disease. Proc Natl Acad Sci USA 107:7969-74 (Abstract)

Eisele YS, Obermuller U, Heilbronner G, Baumann F, Kaeser SA, Wolburg H, Walker LC, Staufenbiel M, Heikenwalder M, Jucker M (2010) Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis. Science 330:980-2 (Abstract)

Jucker M (2010) The benefits and limitations of animal models for translational research inneurodegenerative diseases. Nat Med 16:1210-4 (Abstract) 

Ausgewählte Publikationen 2009 

Eisele YS, Bolmont T, Heikenwalder M, Langer F, Jacobson LH, Yan ZX, Roth K, Aguzzi A, Staufenbiel M, Walker LC, Jucker M (2009) Induction of cerebral beta-amyloidosis: intracerebral versus systemic Abeta inoculation. Proc Natl Acad Scu USA, 106:12926-31 (Abstract)

Grathwohl SA, Kalin RE, Bolmont T, Prokop S, Winkelmann G, Kaeser SA, Odenthal J, Radde R, Eldh T, Gandy S, Aguzzi A, Staufenbiel M, Mathews PM, Wolburg H, Heppner FL, Jucker M (2009) Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia. Nat Neurosci 12:1361-3 (Abstract)

Herzig MC, Eisele YS, Staufenbiel M, Jucker M (2009) E22Q-mutant Abeta peptide (AbetaDutch)increases vascular but reduces parenchymal Abeta deposition. The American Journal of Pathology 174:722-6 (Abstract)

Clavaguera F, Bolmont T, Crowther RA, Abramowski D, Frank S, Probst A, Fraser G, Stalder AK, Beibel M, Staufenbiel M, Jucker M, Goedert M, Tolnay M (2009) Transmission and spreading of tauopathy in transgenic mouse brain. Nature Cell Biology 11:909-13 (Abstract)

Wegenast-Braun BM, Fulgencio Maisch A, Eicke D, Radde R, Herzig MC, Staufenbiel M, Jucker M, Calhoun ME (2009) Independent effects of intra- and extracellular Abeta on learning-related gene expression. American Journal of Pathology 175:271-82 (Abstract) 

Ausgewählte Publikationen 2008 

Jucker M, Heppner FL (2008) Cerebral and peripheral amyloid phagocytes - an old liaison with a new twist. Neuron 59:8-10 (Abstract)

Bolmont T, Haiss F, Eicke D, Radde R, Mathis CA, Klunk WE, Kohsaka S, Jucker M, Calhoun ME (2008) Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenance. Journal of Neuroscience 28:4283-92 (Abstract)

Ermini FV, Grathwohl S, Radde R, Yamaguchi M, Staufenbiel M, Palmer TD, Jucker M (2008) Neurogenesis and alterations of neural stem cells in mouse models of cerebral amyloidosis. American Journal of Pathology 172:1520-8 (Abstract)

Ausgewählte Publikationen 2007 

Burbach GJ, Vlachos A, Ghebremedhin E, del Turco D, Coomaraswamy J, Staufenbiel M, Jucker M, Deller T (2007) Vessel ultrastructure in APP23 transgenic mice after passive anti-Aß immunotherapy and subsequent intracerebral hemorrhage. Neurobiology of Aging, 28:202-12 (Abstract)

Kaeser S, Herzig M, Coomaraswamy J, Kilger E, Selenica ML, Winkler D, Staufenbiel M, Levy E, Grubb A, Jucker M (2007) Cystatin C modulates cerebral ß-amyloidosis, Nature Genetics, 39:1437-9 (Abstract)

Bolmont T, Clavaguera F, Meyer-Luehmann M, Herzig M, Radde R, Staufenbiel M, Lewis J, Hutton M, Tolnay M, Jucker M (2007) Induction of tau pathology by intracerebral infusion of Amyloid-ß-containing brain extract and by Amyloid-ß-deposition in APP x tau transgenic mice, American Journal of Pathology, 171:2012-20 (Abstract)

Eisele Y, Baumann M, Klebl B, Nordhammer C, Jucker M, Kilger E (2007) Gleevec increases levels of the amyloid precursor protein intracellular domain and of the amyloid-ß-degrading enzyme neprilysin, Molecular Biology of the Cell, 18:3591-600 (Abstract)

Herzig MC, Paganetti P, Staufenbiel M, Jucker M (2007) BACE1 and mutated presenilin-1 differently modulate Aß40 and Aß42 levels and cerebral amyloidosis in APPDutch transgenic mice. Neurodegenerative Dis, 4:127-35 (Abstract)

Ausgewählte Publikationen 2006 

Herzig MC, van Nostrand WE, Jucker M (2006) Mechanism of cerebral ß-amyloid angiopathy: murine and cellular models. Brain Pathology 16:40-54 (Abstract)

Walker L, Le Vine III H, Mattson MP, Jucker M (2006) Inducible proteopathies. Trends in Neurosciences 29:438-43 (Abstract)

Walker L, LeVine H, Jucker M (2006) Koch's postulates and transmissible proteopathies. Acta Neuropathol 112:1-4 (Abstract)

Radde R, Bolmont T, Käser SA, Coomaraswamy J, Lindau D, Stoltze L, Calhoun ME, Jäggi F, Wolburg H, Gengler S, Haass C, Ghetti B, Czech C, Hölscher C, Mathews PM, Jucker M (2006) Ab42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology. EMBO reports 7:940-6 (Abstract)

Meyer-Luehmann M, Coomaraswamy J, Bolmont T, Kaeser S, Schaefer C, Kilger E, Neuenschwander A, Abramowski D, Frey P, Jaton AL, Vigouret J, Paganetti P, Walsh DM, Mathews P, Ghiso J, Staufenbiel M, Walker L, Jucker M (2006) Exogenous induction of Ab-amyloidogenesis is governed by agent and host. Science 313:1781-4 (Abstract) 

Ausgewählte Publikationen 2005

Boncristiano S, Calhoun ME, Howard V, Bondolfi L, Kaeser SA, Wiederhold KH, Staufenbiel M, Jucker M (2005) Neocortical synaptic bouton number is maintained despite robust amyloid deposition in APP23 transgenic mice. Neurobiology of Aging 26: 607-13 (Abstract)

Syková E, Voíek I, Antonova T, Mazel T, Meyer-Luehmann M, Jucker M, Hájek M, Ort M, Bure J (2005). Changes in extracellular space size and geometry in APP23 transgenic mice - a model of Alzheimer’s disease. Proc. Natl. Acad. Sci. USA 102: 479-84 (Abstract)

Stalder AK, Ermini F, Bondolfi L, Krenger W, Burbach G, Deller T, Coomaraswamy J, Staufenbiel M, Landmann R, Jucker M (2005) Invasion of hematopoietic cells into the brain of amyloid precursor protein transgenic mice. Journal of Neuroscience 25:11125-32 (Abstract) 

Ausgewählte Publikationen 2004 

Bondolfi L, Ermini F, Long JM, Ingram DK, Jucker M (2004). Impact of age and caloric restriction on neurogenesis in the dentate gyrus of C57BL/6 mice. Neurobiology of Aging 25: 333-40  (Abstract)

Phinney AL, Calhoun ME, Woods AG, Deller T, Jucker M (2004). Stereological analysis of the reorganization of the dentate gyrus following entorhinal cortex lesion in mice. European Journal of Neuroscience 19: 1731-40  (Abstract)

Burbach GJ, Hellweg R, Haas CA, Del Turco D, Deicke U, Abramowski D, Jucker M, Staufenbiel M, Deller T (2004). Induction of brain-derived neurotrophic factor in plaque-associated glial cells of aged APP23 transgenic mice. Journal of Neuroscience 24: 2421-30  (Abstract)

Mueggler T, Meyer-Luehmann M, Rausch M, Staufenbiel M, Jucker M, Rudin M (2004) Restricted diffusion in the brain of transgenic mice with cerebral amyloidosis. European Journal of Neuroscience 20: 811-7  (Abstract)

Herzig MC, Winkler DT, Burgermeister P, Pfeifer M, Kohler E, Schmidt SD, Danner S, Abramowski D, Stürchler-Pierrat C, Bürki K, van Duinen SG, Maat-Schieman MLC, Staufenbiel M, Mathews PM, Jucker M (2004). Aß is targeted to the vasculature in a mouse model of Hereditary Cerebral Hemorrhage with Amyloidosis. Nature Neuroscience 7: 954-60 (Abstract)

Ausgewählte Publikationen < 2004 

Meyer-Luehmann M, Stalder M, Herzig MC, Käser S, Kohler E, Pfeifer M, Boncristiano S, Mathews PM, Mercken M, Abramowski D, Staufenbiel M, Jucker M (2003) Extracellular amyloid formation and associated pathology in neural grafts. Nature Neuroscience 6:370-7 (Abstract)

Pfeifer M, Boncristiano S, Bondolfi L, Stalder A, Deller T, Staufenbiel M, Mathews P, Jucker M (2002) Cerebral hemorrhage following anti-Aß-immunotherapy. Science 298:1379 (Abstract)

Winkler D, Biedermann L, Tolnay N, Allegrini PR, Staufenbiel M, Wiessner C, Jucker M (2002) Thrombolysis induces cerebral hemorrhage in a mouse model of cerebral amyloid angiopathy. Annals of Neurology 51:790-3 (Abstract)

Bondolfi L, Calhoun M, Ermini F, Kuhn HG, Wiederhold KH, Walker L, Staufenbiel M, Jucker M (2002) Amyloid-associated neuron loss and gliogenesis in the neocortex of amyloid precursor protein transgenic mice. Journal of Neuroscience 22:515-22 (Abstract)

Boncristiano S, Calhoun ME, Kelly PH, Pfeifer M, Bondolfi L, Stalder M, Phinney AL, Abramowski D, Sturchler-Pierrat C, Enz A, Sommer B, Staufenbiel M, Jucker M (2002) Cholinergic changes in the APP23 transgenic mouse model of cerebral amyloidosis. Journal of Neuroscience 22:3234-43 (Abstract)

Winkler D, Bondolfi L, Herzig M, Jann L, Calhoun ME, Wiederhold KH, Tolnay M, Staufenbiel, Jucker M (2001) Spontaneous hemorrhagic stroke in a mouse model of cerebral amyloid angiopathy. Journal of Neuroscience 21:1619-27 (Abstract)

Phinney AL, Deller T, Stalder M, Calhoun ME, Frotscher M, Sommer B, Staufenbiel M, Jucker M (1999) Cerebral amyloid induces aberrant axonal sprouting and ectopic terminal formation in amyloid precursor protein transgenic mice. Journal of Neuroscience 19:8552-9 (Abstract) 

Calhoun ME, Burgermeister P, Phinney AL, Stalder M, Tolnay M, Wiederhold KH, Abramowski D, Stürchler-Pierrat C, Sommer B, Staufenbiel M, Jucker M (1999) Neuronal overexpression of mutant APP results in prominent deposition of cerebrovascular amyloid. Proc. Natl. Acad. Sci. USA 96:14088-93 (Abstract)

Calhoun ME, Wiederhold KH, Abramovski D, Phinney AL, Probst A, Sturchler-Pierrat C, Staufenbiel M, Sommer B, Jucker M (1998) Neuron loss in APP transgenic mice. Nature 395:755-6 (Abstract)

Jucker M, Walker LC, Martin L, Kitt C, Kleinman H, Ingram D, Price D, Wirak D, Bayney R, Ramabhadran T, Fracasso R, Hart J, Hauer P, Hsiau P, Pekar S, Scangos G, Trap B, Unterbeck A (1992) Age-Associated Inclusions in Normal and Transgenic Mouse Brain. Science 255:1443-5 (Abstract)