The projects of the Clinical and Experimental Neurooncology Laboratory focus on the biology of tumors of the nervous system, with special emphasis on molecular mechanisms of tumorigenesis, acquired therapy resistance, and treatment-induced vulnerability. Our projects are translationally oriented, i.e. the questions of our projects are based on unsolved clinical challenges. Our ambition is to achieve further development of therapeutic strategies in phase I/II trials. Our research projects thus span the entire translational chain of discovery, validation and application with constant forward and reverse translation.
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Selected Publications (last 3 years)
Merk DJ, Tsiami F, Hirsch S, Walter B, Haeusser LA, Maile JD, Stahl A, Jarboui MA, Lechado-Terradas A, Klose F, Babaei S, Admard J, Casadei N, Roggia C, Spohn M, Schittenhelm J, Singer S, Schüller U, Piccioni F, Persky NS, Claassen M, Tatagiba M, Kahle PJ, Root DE, Templin M, Tabatabai G. Functional screening reveals genetic dependencies and diverging cell cycle control in atypical teratoid rhabdoid tumors. Genome Biol. 2024 Dec 2;25(1):301. doi: 10.1186/s13059-024-03438-w. PMID: 39617889; PMCID: PMC11610224.
Tabatabai G,Platten M, Preusser M, Weller M, Wick W, van den Bent M. Treatment of glioblastoma patients with personalized vaccines outside clinical trials: Lessons ignored? Neuro Oncol. 2024 Nov 19:noae225. doi: 10.1093/neuonc/noae225. Epub ahead of print. PMID: 39561243.
Sahm F, Bertero L, Brandner S, Capper D, Goldbrunner R, […], Tabatabai G, Tabouret E, Short S, Wen PY, Weller M, Le Rhun E, Wesseling P, van den Bent M, Preusser M. EANO guideline on molecular testing of meningiomas for targeted therapy selection. Neuro Oncol. 2024 Nov 22:noae253. doi: 10.1093/neuonc/noae253. Epub ahead of print. PMID: 39577862.
Singer S, Schranz M, Hippler M, Kuchen R, Weiß Lucas C, Meixensberger J, Fehrenbach MK, Keric N, Mitsdoerffer M, Gempt J, Coburger J, Kessler AF, Wehinger J, Misch M, Onken J, Rapp M, Voß M, Nadji-Ohl M, Mehlitz M, Tatagiba M, Tabatabai G, Renovanz M. Frequency and clinical associations of common mental disorders in adults with high-grade glioma-A multicenter study. Cancer. 2024 Nov 17. doi: 10.1002/cncr.35653. Epub ahead of print. PMID: 39550627.
Landry AP, Wang JZ, Patil V, […],Tabatabai G, Tatagiba M, Behling F, Barnholtz-Sloan JS, Sloan AE, Chotai S, Chambless LB, Mansouri A, Ehret F, Capper D, Tsang DS, Aldape K, Gao A; International Consortium on Meningiomas (ICOM); Nassiri F, Zadeh G. Validation and next-generation update of a DNA methylation-based recurrence predictor for meningioma: a multicenter prospective study. Neuro Oncol. 2024 Nov 6:noae236. doi: 10.1093/neuonc/noae236. Epub ahead of print. PMID: 39503370.
Zeyen T, Böhm L, Paech D, […] Tabatabai G, […], Herrlinger U, Weller J, Schaub C. Quantitative assessment of residual tumor is a strong and independent predictor of survival in methylated glioblastoma following radiochemotherapy with CCNU/TMZ. Neuro Oncol. 2024 Oct 1:noae205. doi: 10.1093/neuonc/noae205. Epub ahead of print. PMID: 39351820.
Wang JZ, Patil V, Landry, […] Tabatabai G, Tatagiba M, Behling, […], Aldape K, Nassiri F, Zadeh G. Molecular classification to refine surgical and radiotherapeutic decision-making in meningioma. Nat Med. 2024 Nov;30(11):3173-3183. doi: 10.1038/s41591-024-03167-4. Epub 2024 Aug 21. PMID: 39169220; PMCID: PMC11564112.
Beer SA, Möhle R, Tabatabai G, Merle DA, Ernemann U, Richter V, Lengerke C. Clinical relevance of brain MRI changes in primary central nervous system lymphoma after high-dose-chemotherapy and autologous stem cell transplantation. Bone Marrow Transplant. 2024 Aug 9. doi: 10.1038/s41409-024-02382-4. Epub ahead of print. PMID: 39122834.
Tsiami F, Lago C, Pozza N, Piccioni F, Zhao X, Lülsberg F, Root DE, Tiberi L, Kool M, Schittenhelm J, Bandopadhayay P, Segal RA, Tabatabai G, Merk DJ. Genome-wide CRISPR-Cas9 knockout screens identify DNMT1 as a druggable dependency in sonic hedgehog medulloblastoma. Acta Neuropathol Commun. 2024 Aug 7;12(1):125. doi: 10.1186/s40478-024-01831-x. PMID: 39107797; PMCID: PMC11304869.
Merk DJ, Paul L, Tsiami F, Hohenthanner H, Kouchesfahani GM, Haeusser LA, Walter B, Brown A, Persky NS, Root DE, Tabatabai G.CRISPR-Cas9 screens reveal common essential miRNAs in human cancer cell lines. Genome Med. 2024 Jun 17;16(1):82. doi: 10.1186/s13073-024-01341-4. PMID: 38886809; PMCID: PMC11181638.
Maier SH, Schönecker S, Anagnostatou V, Garny S, Nitschmann A, Fleischmann DF, Büttner M, Kaul D, Imhoff D, Fokas E, Seidel C, Hau P, Kölbl O, Popp I, Grosu AL, Haussmann J, Budach W, Celik E, Kahl KH, Hoffmann E, Tabatabai G, Paulsen F, Holzgreve A, Albert NL, Mansmann U, Corradini S, Belka C, Niyazi M, Bodensohn R. Dummy run for planning of isotoxic dose-escalated radiation therapy for glioblastoma used in the PRIDE trial (NOA-28; ARO-2024-01; AG-NRO-06). Clin Transl Radiat Oncol. 2024 May 4;47:100790. doi: 10.1016/j.ctro.2024.100790. PMID: 38765202; PMCID: PMC11101689.
Feucht D, Haas P, Skardelly M, Behling F, Rieger D, Bombach P, Paulsen F, Hoffmann E, Hauser TK, Bender B, Renovanz M, Niyazi M, Tabatabai G, Tatagiba M, Roder C. Preoperative growth dynamics of untreated glioblastoma: Description of an exponential growth type, correlating factors, and association with postoperative survival. Neurooncol Adv. 2024 Apr 3;6(1):vdae053. doi: 10.1093/noajnl/vdae053. PMID: 38680987; PMCID: PMC11046984.
Dannehl D, Jakob D, Mergel F, Estler A, Engler T, Volmer L, Frevert ML, Matovina S, Englisch A, Tegeler CM, Rohner A, Seller A, Hahn M, Pfister K, Fink A, Popp I, Lorenz S,Tabatabai G, Juhasz-Böss I, Janni W, Brucker S, Taran FA, Hartkopf A, Schäffler H. The efficacy of sacituzumab govitecan and trastuzumab deruxtecan on stable and active brain metastases in metastatic breast cancer patients-a multicenter real-world analysis. ESMO Open. 2024 Apr 17;9(5):102995. doi: 10.1016/j.esmoop.2024.102995. Epub ahead of print. PMID: 38636292.
Walter B, Hirsch S, Kuhlburger L, Stahl A, Schnabel L, Wisser S, Haeusser LA, Tsiami F, Plöger S, Aghaallaei N, Dick AM, Skokowa J, Schmees C, Templin M, Schenke-Layland K, Tatagiba M, Nahnsen S, Merk DJ,Tabatabai G. Functionally-instructed modifiers of response to ATR inhibition in experimental glioma. J Exp Clin Cancer Res. 2024 Mar 12;43(1):77.doi: 10.1186/s13046-024-02995-z. PMID: 38475864; PMCID: PMC10935927.
Dörner L, Grosse L, Stange F, Hille H, Kurz S, Becker H, Volkmer S, Hippler M, Rieger D, Bombach P, Rieger J, Weinert L, Svensson L, Anders C, Cekin S, Paulsen F, Öner Ö, Ruhm K, Malek HS, Möller Y, Tatagiba M, Wallwiener M, Eckert N, Escher P, Pfeifer N, Forschner A, Bauer A, Zips D, Bitzer M, Malek N, Gani C, Tabatabai G, Renovanz M. App-based assessment of patient-reported outcomes in the Molecular Tumor Board in the Center for Personalized Medicine-(TRACE). Neurooncol Pract. 2024 Jan 20;11(3):336-346. doi: 10.1093/nop/npae002. PMID: 38737615; PMCID: PMC11085831.
Bodensohn R, Fleischmann DF, Maier SH, Anagnostatou V, Garny S, Nitschmann A, Büttner M, Mücke J, Schönecker S, Unger K, Hoffmann E, Paulsen F, Thorwarth D, Holzgreve A, Albert NL, Corradini S, Tabatabai G, Belka C, Niyazi M. Dosimetric feasibility analysis and presentation of an isotoxic dose-escalated radiation therapy concept for glioblastoma used in the PRIDE trial (NOA-28; ARO-2022-12). Clin Transl Radiat Oncol. 2023 Dec 3;45:100706. doi: 10.1016/j.ctro.2023.100706. PMID: 38116137; PMCID: PMC10726217.
Kurz SC, Stammberger A, Rosahl SK, Abrey LE, Albert NL, Baumgarten LV, Gempt J, Grosu AL, Leidgens V, McLean A, Renovanz M, Schwarzenberger J, Sevenich L, Urbanic Purkart T, Combs SE, Tabatabai G, Hegi M, Nowosielski M. Towards more Diversity in Neuro-oncology Leadership-the DivINe Initiative. Neuro Oncol. 2023 Sep 21:noad157. doi: 10.1093/neuonc/noad157. Epub ahead of print. PMID: 37738478.
Behling F, Paßlack P, Fodi CK, Hielscher T, Schittenhelm J, Nassiri F, Wang JZ, Zadeh G, Tabatabai G, Sahm F. Loss of H3K27me3 in meningiomas: an independent marker for CNS WHO grade 2? Neurooncol Adv. 2023 Sep 2;5(1):vdad112. doi: 10.1093/noajnl/vdad112. PMID: 37727848; PMCID: PMC10506376.
Roder C, Stummer W, Coburger J, Scherer M, Haas P, von der Brelie C, Kamp MA, Löhr M, Hamisch CA, Skardelly M, Scholz T, Schipmann S, Rathert J, Brand CM, Pala A, Ernemann U, Stockhammer F, Gerlach R, Kremer P, Goldbrunner R, Ernestus RI, Sabel M, Rohde V, Tabatabai G, Martus P, Bisdas S, Ganslandt O, Unterberg A, Wirtz CR, Tatagiba M. Intraoperative MRI-Guided Resection Is Not Superior to 5-Aminolevulinic Acid Guidance in Newly Diagnosed Glioblastoma: A Prospective Controlled Multicenter Clinical Trial. J Clin Oncol. 2023 Jun 19:JCO2201862. doi: 10.1200/JCO.22.01862. Epub ahead of print. PMID: 37335962.
Illert AL, Stenzinger A, Bitzer M, Horak P, Gaidzik VI, Möller Y, Beha J, Öner Ö, Schmitt F, Laßmann S, Ossowski S, Schaaf CP, Hallek M, Brümmendorf TH, Albers P, Fehm T, Brossart P, Glimm H, Schadendorf D, Bleckmann A, Brandts CH, Esposito I, Mack E, Peters C, Bokemeyer C, Fröhling S, Kindler T, Algül H, Heinemann V, Döhner H, Bargou R, Ellenrieder V, Hillemanns P, Lordick F, Hochhaus A, Beckmann MW, Pukrop T, Trepel M, Sundmacher L, Wesselmann S, Nettekoven G, Kohlhuber F, Heinze O, Budczies J, Werner M, Nikolaou K, Beer AJ, Tabatabai G, Weichert W, Keilholz U, Boerries M, Kohlbacher O, Duyster J, Thimme R, Seufferlein T, Schirmacher P, Malek NP. The German Network for Personalized Medicine to enhance patient care and translational research. Nat Med. 2023 Jun;29(6):1298-1301. doi: 10.1038/s41591-023-02354-z. PMID: 37280276.
Wang JZ, Patil V, Liu J, Dogan H, Tabatabai G, Yefet LS, Behling F, Hoffman E, Bunda S, Yakubov R, Kaloti R, Brandner S, Gao A, Cohen-Gadol A, Barnholtz-Sloan J, Skardelly M, Tatagiba M, Raleigh DR, Sahm F, Boutros PC, Aldape K; International Consortium on Meningiomas (ICOM); Nassiri F, Zadeh G. Increased mRNA expression of CDKN2A is a transcriptomic marker of clinically aggressive meningiomas. Acta Neuropathol. 2023 Jul;146(1):145-162. doi: 10.1007/s00401-023-02571-3. Epub 2023 Apr 24. Acta Neuropathol. 2023 May 12;: PMID: 37093270; PMCID: PMC10261216.
Koch MS, Zdioruk M, Nowicki MO, Hoetker MS, Herbert ZT, Barone F, Tak PP, Chiocca EA, Tabatabai G, Lawler SE. Uncovering transcriptomic landscape alterations of CAN-2409 in in vitro and in vivo glioma models. Front Med (Lausanne). 2023 May 9;10:1140352. doi: 10.3389/fmed.2023.1140352. PMID: 37228396; PMCID: PMC10203593.
Weller M, Le Rhun E, Van den Bent M, Chang SM, Cloughesy TF, Goldbrunner R, Hong YK, Jalali R, Jenkinson MD, Minniti G, Nagane M, Razis E, Roth P, Rudà R, Tabatabai G, Wen PY, Short SC, Preusser M. Diagnosis and management of complications from the treatment of primary central nervous system tumors in adults. Neuro Oncol. 2023 Jul 6;25(7):1200-1224. doi: 10.1093/neuonc/noad038. PMID: 36843451; PMCID: PMC10326495.
Beer SA, Wirths S, Vogel W, Tabatabai G, Ernemann U, Merle DA, Bethge W, Möhle R, Lengerke C (2023) Patient Reported and Clinical Outcomes after High-Dose Chemotherapy and Autologous Stem Cell Transplantation in Primary Central Nervous System Lymphoma Cancers (Basel) 15(3):669
Capper D, Reifenberger G, French PJ, Schweizer L, Weller M, Touat M, Niclou SP, Euskirchen P, Haberler C, Hegi ME, Brandner S, Le Rhun E, Rudà R, Sanson M, Tabatabai G, Sahm F, Wen PY, Wesseling P, Preusser M, van den Bent MJ. EANO guideline on rational molecular testing of gliomas, glioneuronal and neuronal tumors in adults for targeted therapy selection. Neuro Oncol. 2023 Jan 12:noad008. doi: 10.1093/neuonc/noad008.
Becker, H.; Castaneda-Vega, S.; Patzwaldt, K.; Przystal, J.M.; Walter, B.; Michelotti, F.C.; Canjuga, D.; Tatagiba, M.; Pichler, B.; Beck, S.C.; Holland, E.C.; la Fougère, C.; Tabatabai, G. Multiparametric Longitudinal Profiling of RCAS-tva-Induced PDGFB-Driven Experimental Glioma. Brain Sci. 2022, 12, 1426. doi.org/10.3390/brainsci12111426
Koch MS, Zdioruk M, Nowicki MO, Griffith AM, Aguilar-Cordova E, Aguilar LK, Guzik BW, Barone F, Tak PP, Schregel K, Hoetker MS, Lederer JA, Chiocca EA, Tabatabai G, Lawler SE. Perturbing DDR signaling enhances cytotoxic effects of local oncolytic virotherapy and modulates the immune environment in glioma. Mol Ther Oncolytics. 2022 Jul 31;26:275-288. doi: 10.1016/j.omto.2022.07.009. PMID: 36032633; PMCID: PMC9391522.
Omuro A, Brandes AA, Carpentier AF, Idbaih A, Reardon DA, Cloughesy T, Sumrall A, Baehring J, van den Bent M, Bähr O, Lombardi G, Mulholland P, Tabatabai G, Lassen U, Sepulveda JM, Khasraw M, Vauleon E, Muragaki Y, Di Giacomo AM, Butowski N, Roth P, Qian X, Fu AZ, Liu Y, Potter V, Chalamandaris AG, Tatsuoka K, Lim M, Weller M. Radiotherapy Combined With Nivolumab or Temozolomide for Newly Diagnosed Glioblastoma With Unmethylated MGMT Promoter: An International Randomized Phase 3 Trial. Neuro Oncol. 2022 Apr 14:noac099. doi: 10.1093/neuonc/noac099. Epub ahead of print.
Trautwein C, Zizmare L, Mäurer I, Bender B, Bayer B, Ernemann U, Tatagiba M, Grau SJ, Pichler BJ, Skardelly M, Tabatabai G. Tissue metabolites in diffuse glioma and their modulations by IDH1 mutation, histology, and treatment. JCI Insight. 2022 Feb 8;7(3):e153526. doi: 10.1172/jci.insight.
Walter B, Canjuga D, Yüz SG, Ghosh M, Bozko P, Przystal JM, Govindarajan P, Anderle N, Keller A-L, Tatagiba M, Schenke-Layland K, Rammensee H-G, Stevanovic S, Malek NP, Schmees C, Tabatabai G. Argyrin F Treatment-Induced Vulnerabilities Lead to a Novel Combination Therapy in Experimental Glioma. Adv. Therap. 2021, 2100078.
Nassiri F, Liu J, Patil V, Mamatjan Y, Wang JZ, Hugh-White R, Macklin AM, Khan S, Singh O, Karimi S, Corona RI, Liu LY, Chen CY, Chakravarthy A, Wei Q, Mehani B, Suppiah S, Gao A, Workewych AM, Tabatabai G, Boutros PC, Bader GD, de Carvalho DD, Kislinger T, Aldape K, Zadeh G. A clinically applicable integrative molecular classification of meningiomas. Nature. 2021 Sep;597(7874):119-125. doi: 10.1038/s41586-021-03850-3. Epub 2021 Aug 25.
Goldbrunner R, Stavrinou P, Jenkinson MD, Sahm F, Mawrin C, Weber DC, Preusser M, Minniti G, Lund-Johansen M, Lefranc F, Houdart E, Sallabanda K, Le Rhun E, Nieuwenhuizen D, Tabatabai G, Soffietti R, Weller M. EANO guideline on the diagnosis and management of meningiomas. Neuro Oncol. 2021 Nov 2;23(11):1821-1834. doi: 10.1093/neuonc/noab150.
Przystal JM, Becker H, Canjuga D, Tsiami F, Anderle N, Keller AL, Pohl A, Ries CH, Schmittnaegel M, Korinetska N, Koch M, Schittenhelm J, Tatagiba M, Schmees C, Beck SC, Tabatabai G. Targeting CSF1R Alone or in Combination with PD1 in Experimental Glioma. Cancers (Basel). 2021 May 15;13(10):2400. doi: 10.3390/cancers13102400.
Platten M, Bunse L, Wick A, Bunse T, Le Cornet L, Harting I, Sahm F, Sanghvi K, Tan CL, Poschke I, Green E, Justesen S, Behrens GA, Breckwoldt MO, Freitag A, Rother LM, Schmitt A, Schnell O, Hense J, Misch M, Krex D, Stevanovic S, Tabatabai G, Steinbach JP, Bendszus M, von Deimling A, Schmitt M, Wick W. A vaccine targeting mutant IDH1 in newly diagnosed glioma. Nature. 2021 Apr;592(7854):463-468. doi: 10.1038/s41586-021-03363-z. Epub 2021 Mar 24.
Wick A, Bähr O, Schuler M, Rohrberg K, Chawla SP, Janku F, Schiff D, Heinemann V, Narita Y, Lenz HJ, Ikeda M, Ando Y, Wick W, Steinbach JP, Burger MC, Wenger K, Lassen U, Sankhala KK, Roggia C, Genvresse I, Munhoz C, Rentzsch C, Reschke S, Langer S, Wagner M, Kaulfuss S, Cai C, Lagkadinou E, Jeffers M, Peña C, Tabatabai G. Phase I Assessment of Safety and Therapeutic Activity of BAY1436032 in Patients with IDH1-Mutant Solid Tumors. Clin Cancer Res. 2021 May 15;27(10):2723-2733. doi: 10.1158/1078-0432.CCR-20-4256. Epub 2021 Feb 23.
Behling F, Fodi C, Gepfner-Tuma I, Kaltenbach K, Renovanz M, Paulsen F, Skardelly M, Honegger J, Tatagiba M; International Consortium on Meningiomas, Schittenhelm J, Tabatabai G. H3K27me3 loss indicates an increased risk of recurrence in the Tübingen meningioma cohort. Neuro Oncol. 2021 Aug 2;23(8):1273-1281. doi: 10.1093/neuonc/noaa303.
Herrlinger U, Tzaridis T, Mack F, Steinbach JP, Schlegel U, Sabel M, Hau P, Kortmann RD, Krex D, Grauer O, Goldbrunner R, Schnell O, Bähr O, Uhl M, Seidel C, Tabatabai G, Kowalski T, Ringel F, Schmidt-Graf F, Suchorska B, Brehmer S, Weyerbrock A, Renovanz M, Bullinger L, Galldiks N, Vajkoczy P, Misch M, Vatter H, Stuplich M, Schäfer N, Kebir S, Weller J, Schaub C, Stummer W, Tonn JC, Simon M, Keil VC, Nelles M, Urbach H, Coenen M, Wick W, Weller M, Fimmers R, Schmid M, Hattingen E, Pietsch T, Coch C, Glas M; Neurooncology Working Group of the German Cancer Society. Lomustine-temozolomide combination therapy versus standard temozolomide therapy in patients with newly diagnosed glioblastoma with methylated MGMT promoter (CeTeG/NOA-09): a randomised, open-label, phase 3 trial. Lancet. 2019 Feb 16;393(10172):678-688. doi: 10.1016/S0140-6736(18)31791-4. Epub 2019 Feb 14.
We collaborate closely with national and international partners and alliances, including:
- Deutsches Gliomnetzwerk (German Glioma Network)
- the German Cancer Consortium (Deutsches Konsortium für Translationale Krebsforschung, DKTK)
- the European Organisation for Research and Treatment of Cancer (EORTC)
- the European Association of Neuro-Oncology (EANO)
- the International Consortium on Meningioma (ICOM)
Hertie Center of Neurology
Hertie Institute for Clinical Brain Research
Department of Neurology & Interdisciplinary Neuro-Oncology
Otfried-Müller-Straße 27
72076 Tübingen
Phone: +49 (0)7071 29-85018
Fax: +49 (0)7071 29-5957
Phone: +49 (0)7071 29-83269
