1. Longitudinal analysis of clinical, neuropsychological, biofluid, and imaging modalities in familial Alzheimer's disease for the further understanding of sporadic Alzheimer's disease…
Hofmann A, Häsler LM, Lambert M, Kaeser SA, Gräber-Sultan S, Obermüller U, Kuder-Buletta E, la Fougere C, Laske C, Vöglein J, Levin J, Fox NC, Ryan NS, Zetterberg H, Llibre-Guerra JJ, Perrin RJ,…
A seminal finding from our group was the observation that misfolded Aβ can act as a seed to induce further Aß misfolding and aggregation in a manner that is strikingly similar to prion…
Cerebral proteopathy is a unifying term for neurodegenerative diseases in which aggregated proteins are abnormally deposited in the brain. The hallmark proteopathy is Alzheimer’s disease (AD). In…
1. To understand how Aβ aggregation originates, spreads, and leads to neuronal dysfunction and dementia.
2. To study non-Aβ proteopathies in order to determine their similarities and…
Full list of publications
Selected publications
Hofmann A, Häsler LM, Lambert M, Kaeser SA, Gräber-Sultan S, Obermüller U, Kuder-Buletta E, la Fougere C, Laske C, Vöglein J, Levin J,…
Cerebral proteopathy is a unifying term for neurodegenerative diseases in which aggregated proteins are abnormally deposited in the brain. The hallmark proteopathy is Alzheimer’s disease (AD). In…
About us
Our research focus is on the cellular and molecular mechanisms of brain aging and age-related neurodegenerative diseases, with a special emphasis on the pathogenesis of Alzheimer's…
Our research focus is on the cellular and molecular mechanisms of brain aging and age-related neurodegenerative diseases, with a special emphasis on the pathogenesis of Alzheimer's disease and…
Prof. Matthis Synofzik, head of the section “Translational Genomics of Neurodegenerative Diseases” at the HIH, speaks in an interview with Deutschlandfunk about individually tailored RNA therapies…
